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Microbiology and Infectious Disease

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Matrix Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF) MS for the Diagnosis of Infectious Diseases

Matrix Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF) MS for the Diagnosis of Infectious DiseasesRobin Patel, M.D., recently reviewed MALDI-TOF MS in Clinical Chemistry, providing a historical perspective on this new technology. MALDI-TOF MS is used as a tool for rapid, accurate, and cost-effective identification of cultured bacteria and fungi in clinical microbiology.

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Mycobacteria Part 3: Drug Susceptibility Testing for Mycobacterium tuberculosis Complex

Mycobacteria Part 3: Drug Susceptibility Testing for <em>Mycobacterium tuberculosis</em> Complex [Hot Topic]Tuberculosis remains a significant disease worldwide. Many TB patients are infectious and capable of spreading the disease to others. Several methods are available to detect drug resistance in M. tuberculosis complex. This is the final presentation in a 3-part review of TB.

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Detecting Herpes Simplex Virus Using a Commercial Real-Time PCR Assay

Detecting Herpes Simplex Virus Using a Commercial Real-Time PCR AssayCentral nervous system infection due to herpes simplex virus (HSV) is a medical emergency and requires a rapid diagnosis and initiation of therapy. A recent study published in the Journal of Clinical Microbiology by Matthew Binnicker, Ph.D., Mark Espy, and Cole Irish, compared a routine real-time PCR assay for HSV type 1 (HSV-1) and HSV-2 to a recently FDA-approved direct PCR assay using cerebrospinal fluid samples.

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