A recent study in Clinical Cancer Research, completed by Mayo Clinic researchers, examined tissue specimens at diagnosis from patients with follicular lymphoma that later transformed to define cell subtypes associated with transformation.
Mayo Clinic researchers, first author Ayalew Tefferi, M.D., in collaboration with the French consortium for CMML, conducted a study published in Leukemia to clarify the prognostic relevance of ASXL1 and SETBP1 mutations, among others, in World Health Organization-defined CMML and its added value to the Mayo prognostic model.
Flow cytometry immunophenotyping has been suggested as an adjunctive technique in the evaluation of myeloid malignancies, especially in the myelodysplastic syndromes. Its use, however, has been limited due to complexity and cost restraints. A recent study by Mayo Clinic was completed to attempt a simpler approach to flow cytometry immunophenotyping in myeloid neoplasms.
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