Chromosome Analyses for Neoplastic Disorders
- Chromosome Analysis, For Hematologic Disorders,
Bone Marrow
- Chromosome Analysis, For Hematologic Disorders,
Blood
- Chromosome Analysis, Lymph Node
- Chromosomes, Body Fluid
FISH
studies for Neoplastic Disorders
- The
following FISH tests/panels are also listed below
by corresponding disorder.
- B-Cell Lymphoma, FISH, Blood or Bone Marrow
- B-Cell Lymphoma, FISH, Tissue
- BCR/ABL,
Translocation 9;22, FISH (D-FISH)
- XX/XY in Opposite Sex Bone Marrow Transplantation,
FISH
- Chromosome Anomalies, Unspecified Miscellaneous with Chromosome-Specific FISH Probes
- B-Cell Acute Lymphoblastic Leukemia (ALL), FISH
- Chronic Lymphocytic Leukemia (CLL), FISH
- Plasma Cell Proliferative Disorder (PCPD),
FISH
- CHIC2 Anomalies at 4q12, FISH
- Myelodysplastic Syndrome (MDS), FISH
- PDGFRB/TEL Translocation
(5;12) for Chronic Myelomonocytic Leukemia,
FISH
- Acute Myeloid Leukemia (AML), FISH
- T-Cell Acute Lymphoblastic Leukemia (T-ALL), FISH
- T-Cell Lymphoma, FISH, Blood or Bone Marrow
Acute
Lymphoblastic Leukemia (ALL) - B-Cell
- B-Cell Acute Lymphoblastic Leukemia (ALL), FISH
- Panel,
recommended for pediatric patients, includes testing
for the following anomalies via the probes listed:
- t(9;22),
ABL1/BCR
- t(12;21), ETV6/RUNX1
- t(1;19), PBX1/TCF3
- +4,
+10, +17, Cen4/10/17
- t(11q23;var), MLL
- del
(9p), CDKN2A/Cen9
- Pediatric
patients: Please indicate if you would like the
entire panel. This is suggested for pediatric
patients with a new diagnosis. If patient is
being tracked for known anomalies, please indicate
which anomalies need to be investigated.
- Adult
patients: Only FISH for ABL1/BCR and MLL are recommended in adult patients with B-Cell ALL.
Acute
Lymphoblastic Leukemia (ALL) – T-Cell
- T-Cell Acute Lymphoblastic Leukemia (T-ALL), FISH
- Please
indicate that the patient has pre-T cell ALL.
- ABL1/NUP214 co-amplification, ABL1/NUP214/Cen 9
- del(9)(p21), CDKN2A/Cen9
- t(11;var)(q23;var), MLL
Acute
Myeloid Leukemia (AML)
- Acute Myeloid Leukemia (AML), FISH
- Please
indicate subtype as well as which anomalies need
to be investigated, from the following profile:
- t(8;21),
[M2], RUNX1T1/RUNX1
- t(15;17),
[M3], PML/RARA
- t(11q23;var),
[M0-M7], MLL
- inv(16),
[M4, Eos], MYH11/CBFbeta
- +8,
[M0-M7], Cen8/c-MYC
- t(6;9),
[M2, M4], DEK/NUP214
- inv(3),
[M1,2,4,6,7], RPN1/MECOM
Chronic
Lymphocytic Leukemia (CLL)
- Chronic Lymphocytic Leukemia (CLL), FISH
- FISH panel is recommended in place of chromosome
analysis for this disorder. Panel includes testing
for the following anomalies via the probes listed:
- 6q-,
c-MYB/Cen6
- 11q-, ATM/Cen11
- +12,
D12Z3/MDM2
- 13q-,
D13S319/LAMP1
- 17p-, TP53/Cen17
- t(11;14), CCND1/IgH
- reflex
for IgH anomaly:
- t(14;18), IgH
/BCL2
- t(14;19), IgH
/BCL3
Chronic
Myeloid Leukemia (CML)
- BCR/ABL,
Translocation 9;22, FISH
Chronic
Myelomonocytic Leukemia (CMML)
- PDGFRB/TEL, Translocation
(5;12) for Chronic Myelomonocytic Leukemia,
FISH
Hypereosinophilic
Syndrome
- CHIC2 Anomalies at 4q12 Deletion, FISH
Imatinib Mesylate Responsive Genes
- Imatinib Mesylate Responsive Genes, FISH
- Panel,
recommended for pediatric patients, includes testing
for the following anomalies via the probes listed:
- 1q25 anomalies, ABL2
- 4q12 anomalies, PDGFRA
- 5q33 anomalies, PDGFRB
- 9q34 anomalies, ABL1
- B-Cell Lymphoma, FISH, Blood or Bone Marrow
- Includes
a mini-pathology consult to evaluate appropriate
FISH probes and translocations to investigate.
Panel includes testing for the following anomalies
via the probes listed:
- t(8;14), c-MYC/IGH
- t(8q24.1;var), c-MYC
- t(11;14), CCND1/IGH
- t(11;18), BIRC3/MALT1
- t(14;18), IGH/MALT1
- t(14;18), IGH/BCL2
- t(3;var), BCL6
- B-Cell Lymphoma, FISH, Tissue
- Includes
a mini-pathology consult to evaluate appropriate
FISH probes and translocations to investigate.
Panel includes testing for the following anomalies
via the probes listed:
- t(11;14), CCND1/IGH
- t(14;18), IGH/BCL2
- t(8q24.1;var), c-MYC
- t(8;14), c-MYC/IGH
- t(11;18)
, BIRC3/MALT1
- reflex t(14;18), IGH/MALT1
- Cen3/Cen7
- Cen12/Cen18
- t(3q27;var), BCL6
- T-Cell Lymphoma, FISH, Blood or Bone Marrow
- Includes
a mini-pathology consult to evaluate appropriate
FISH probes and translocations to investigate.
Panel includes testing for the following anomalies
via the probes listed:
- t(14;var)(q32.1;var), TCL1
- -7/7q-/i(7q), D7S486/cen7
- +8, cen8/c-MYC
- T-Cell Lymphoma, FISH, Tissue
- Includes
a mini-pathology consult to evaluate appropriate
FISH probes and translocations to investigate.
Panel includes testing for the following anomalies
via the probes listed:
- t(14;var)(q32.1;var), TCL1
- -7/7q-/i(7q), D7S486/cen7
- +8, cen8/ c-MYC
- t(2;var)(p23.2;var)/inv(2) ALK
- ABL1/NUP214 co-amplication, ABL1/NUP214/Cen9
- del(9)(p21) CDKN2A/Cen9
- t(11;var)(q23;var) MLL
Myelodysplastic
Syndrome (MDS)
- MDS, Locus Anomalies, FISH
- Chromosome
analysis is recommended as first tier testing
for this disorder; FISH should be used if chromosomes
are not successful.
- Panel
includes testing for the following anomalies via
the probes listed:
- -5/5q-,/EGR1/D5S630
- -7/7q-,
D7S486/Cen7
- +8,
Cen8/c-MYC
- 13q-,
D13S319/LAMP1
- 20q-, 20qter/D20S108
- inv(3), RPN1/MECOM
- Please
indicate if you would like us to run the entire
panel. This is suggested for patients with a
new diagnosis. If patient is being tracked for
known anomalies, please indicate which anomalies
need to be investigated.
Plasma
Cell Proliferative Disorder (PCPD)
- Plasma Cell Proliferative Disorder (PCPD),
FISH
- Testing
for Multiple Myeloma, intended for diagnosis only.
Fresh bone marrow specimen is required.
- Panel
includes testing for the following anomalies via
the probes listed:
- -13/13q-, Rb1/LAMP1
- t(11;14), CCND1/IGH
- t(14;var), IGH
- 17p-, TP53/Cen17
- +3/+7,
Cen3/Cen7
- +9/+15,
Cen9/Cen15
- t(4;14) IGH
reflex, FGFR3/IGH
- t(14;16) IGH
reflex, IGH/MAF
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